Indian Institute of Technology Kanpur
|Doctoral Researcher, Chemical Engineering
Kanpur, Uttar Pradesh, India
Summary
Led comprehensive PhD research in chemical engineering, focusing on mathematical modeling and simulation of biochemical systems to advance understanding of neurodegenerative diseases.
Highlights
Developed and validated complex ODE-based nonlinear/stiff mathematical and kinetic models through MATLAB simulations, integrating experimental data to accurately represent biochemical systems.
Conducted extensive numerical simulations and non-linear parameter tuning, sensitivity, and stability analyses for multi-pathway reaction systems, enhancing model robustness and predictive power.
Pioneered kinetic reaction modeling of amyloid-beta aggregation dynamics in Alzheimer's disease, specifically investigating reactive oxygen species-mediated polymerization and inhibitory mechanisms of small molecules.
Engineered mathematical models for the inhibition and degradation kinetics of amyloid-beta fibrils by large molecule drugs, contributing to novel insights into therapeutic strategies.
Designed and implemented an AI/ML and bioinformatics pipeline to analyze large biological datasets, successfully identifying biomarker genes and informing drug repurposing strategies for Alzheimer's disease.
Authored 6 peer-reviewed publications and delivered 3 conference presentations (2 oral, 1 poster), effectively disseminating complex research findings in chemical engineering and biomedical applications.