Highly accomplished Chemical Engineer with a PhD from IIT Kanpur, specializing in advanced mathematical modeling, reaction engineering, and deep simulation of biochemical systems. Expertly applies AI/ML and bioinformatics tools to analyze large biological datasets, identify key patterns, and repurpose drugs, with a proven track record of developing complex differential equation-based kinetic models for neurodegenerative diseases. Driven to integrate data-driven insights with mechanistic mathematical modeling to drive innovation in biomedical research and drug discovery.
Doctoral Researcher, Chemical Engineering
Kanpur, Uttar Pradesh, India
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Summary
Led comprehensive PhD research in chemical engineering, focusing on mathematical modeling and simulation of biochemical systems to advance understanding of neurodegenerative diseases.
Highlights
Developed and validated complex ODE-based nonlinear/stiff mathematical and kinetic models through MATLAB simulations, integrating experimental data to accurately represent biochemical systems.
Conducted extensive numerical simulations and non-linear parameter tuning, sensitivity, and stability analyses for multi-pathway reaction systems, enhancing model robustness and predictive power.
Pioneered kinetic reaction modeling of amyloid-beta aggregation dynamics in Alzheimer's disease, specifically investigating reactive oxygen species-mediated polymerization and inhibitory mechanisms of small molecules.
Engineered mathematical models for the inhibition and degradation kinetics of amyloid-beta fibrils by large molecule drugs, contributing to novel insights into therapeutic strategies.
Designed and implemented an AI/ML and bioinformatics pipeline to analyze large biological datasets, successfully identifying biomarker genes and informing drug repurposing strategies for Alzheimer's disease.
Authored 6 peer-reviewed publications and delivered 3 conference presentations (2 oral, 1 poster), effectively disseminating complex research findings in chemical engineering and biomedical applications.
Teaching Assistant & Tutor, Chemical Engineering
Kanpur, Uttar Pradesh, India
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Summary
Provided comprehensive instructional and academic support across multiple chemical engineering courses, enhancing student learning and departmental operations.
Highlights
Taught Computer Methods for Engineers (ESC113M) to over 100 students, preparing MATLAB-based problems and conducting classes for numerical solutions.
Managed grading for 100+ student answer sheets and assisted in conducting lab sessions and examinations, ensuring fair and accurate assessment.
Served as a Teaching Assistant for 7 diverse courses, including Mass Transfer, Unit Operations Lab, Computational Methods, Mathematical Methods, and Data Science for Chemical Engineers.
Contributed to the development of course materials and provided direct support to students, significantly improving comprehension of complex engineering concepts.
Master's Researcher, Chemical Engineering
Kanpur, Uttar Pradesh, India
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Summary
Conducted Master's research within a joint MTech-PhD program, focusing on nucleated polymerization modeling relevant to Alzheimer's disease mechanisms.
Highlights
Investigated nucleated polymerization of abnormal amyloid beta, contributing to foundational understanding of Alzheimer's disease pathogenesis.
Implemented MATLAB solvers, including LSQNONLIN and Genetic Algorithm, to accurately model complex biological systems and optimize parameters.
Undergraduate Researcher, Chemical Engineering
Hamirpur, Himachal Pradesh, India
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Summary
Executed an undergraduate research project focused on environmental engineering, specifically the removal of Cr (III) from solutions using sustainable adsorbents.
Highlights
Designed and conducted experiments to analyze the impact of pH and contact time on the efficiency of Cr (III) extraction.
Performed quantitative analysis to determine the percentage removal of Cr (III), achieving measurable results in heavy metal remediation.
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PhD
Chemical Engineering
Grade: CGPA: 7.33/10
Courses
Thesis: Modeling ROS Mediated Amyloid Beta Aggregation and the Role of Different Inhibitors
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MTech
Chemical Engineering
Grade: CGPA: 7.33/10
Courses
Thesis: Nucleated Polymerization Modeling of Alzheimer's Disease Based on Amyloid Beta Hypothesis
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Bachelor
Chemical Engineering
Grade: CGPA: 8.72/10
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High School Diploma
General Studies
Grade: 89.4%
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High School Diploma
General Studies
Grade: 87.2%
Awarded By
IIT Kanpur
Awarded for demonstrating outstanding research capabilities as an exceptional full-time PhD student.
Awarded By
DOAA, IIT Kanpur
Granted to present research at ESCAPE-PSE conference in Italy.
Awarded By
Ministry of Education (MoE), Government of India
Received to support doctoral research.
Awarded By
N/A
Qualified the Graduate Aptitude Test in Engineering examination in Chemical Engineering.
Awarded By
G.M.A.M. Inter College, U.P. Board
Achieved the highest rank in the Intermediate (XII) examination.
Awarded By
G.M.A.M. Inter College, U.P. Board
Achieved the highest rank in the High School (X) examination.
Published by
Elsevier
Summary
Research on kinetic modeling of amyloid beta polymerization and bromocriptine's anti-amyloidogenic activity.
Mathematical Modeling, System Biology, Mathematical & Computational Biology, Bio-Chemical Reaction Engineering, Differential Equations, Numerical Simulations, Parameter Estimation, Sensitivity Analysis, Stability Analysis, Kinetic Modeling, ODEs, Nonlinear Systems, Stiff Systems, Multi-pathway Reaction Systems.
MATLAB, Python, pandas, scikit-learn, matplotlib, seaborn, C/C++, MS Office, LaTeX.
AI/ML, Bioinformatics, Data Analysis, Regression, Classification, SVM, RF, ANNs, PINNs, Biomarker Identification, Drug Repurposing, Network Analysis.
Alzheimer's Disease, Amyloid-beta Aggregation, Neurodegenerative Diseases, Reactive Oxygen Species, Chemical Engineering.
Experimental Data Integration, Problem Solving, Data-Driven Insights, Mechanistic Mathematical Modelling.
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Summary
Presented research findings on the mathematical modeling of reactive oxygen species-triggered nucleated amyloid beta aggregation.
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Summary
Presented poster detailing research on the modeling of ROS-initiated amyloid aggregation and the inhibitory effects of chlorogenic acid.
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Summary
Delivered an oral presentation on the kinetic modeling of reactive oxygen species-initiated amyloid polymerization.